The pathobiology of human fungal infections.
Nat Rev Microbiol
; 22(11): 687-704, 2024 Nov.
Article
in En
| MEDLINE
| ID: mdl-38918447
ABSTRACT
Human fungal infections are a historically neglected area of disease research, yet they cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of these infections has increased considerably over the past decade, through major insights into both the host and pathogen factors that contribute to the phenotype and severity of these diseases. Recent studies are revealing multiple mechanisms by which fungi modify and manipulate the host, escape immune surveillance and generate complex comorbidities. Although the emergence of fungal strains that are less susceptible to antifungal drugs or that rapidly evolve drug resistance is posing new threats, greater understanding of immune mechanisms and host susceptibility factors is beginning to offer novel immunotherapeutic options for the future. In this Review, we provide a broad and comprehensive overview of the pathobiology of human fungal infections, focusing specifically on pathogens that can cause invasive life-threatening infections, highlighting recent discoveries from the pathogen, host and clinical perspectives. We conclude by discussing key future challenges including antifungal drug resistance, the emergence of new pathogens and new developments in modern medicine that are promoting susceptibility to infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Resistance, Fungal
/
Host-Pathogen Interactions
/
Fungi
/
Mycoses
/
Antifungal Agents
Limits:
Humans
Language:
En
Journal:
Nat Rev Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Document type:
Article
Country of publication: