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Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2.
Lee, Lawrance; French, Evan; Coelho, Daniel H; Manzoor, Nauman F; Wilcox, Adam B; Lee, Adam M; Graves, Alexis; Anzalone, Alfred; Manna, Amin; Saha, Amit; Olex, Amy; Zhou, Andrea; Williams, Andrew E; Southerland, Andrew; Girvin, Andrew T; Walden, Anita; Sharathkumar, Anjali A; Amor, Benjamin; Bates, Benjamin; Hendricks, Brian; Patel, Brijesh; Alexander, Caleb; Bramante, Carolyn; Ward-Caviness, Cavin; Madlock-Brown, Charisse; Suver, Christine; Chute, Christopher; Dillon, Christopher; Wu, Chunlei; Schmitt, Clare; Takemoto, Cliff; Housman, Dan; Gabriel, Davera; Eichmann, David A; Mazzotti, Diego; Brown, Don; Boudreau, Eilis; Hill, Elaine; Zampino, Elizabeth; Marti, Emily Carlson; Pfaff, Emily R; French, Evan; Koraishy, Farrukh M; Mariona, Federico; Prior, Fred; Sokos, George; Martin, Greg; Lehmann, Harold; Spratt, Heidi; Mehta, Hemalkumar.
Affiliation
  • Lee L; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • French E; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Coelho DH; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Manzoor NF; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Wilcox AB; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Lee AM; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Graves A; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Anzalone A; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Manna A; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Saha A; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Olex A; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Zhou A; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Williams AE; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Southerland A; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Girvin AT; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Walden A; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Sharathkumar AA; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Amor B; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Bates B; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Hendricks B; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Patel B; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Alexander C; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Bramante C; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Ward-Caviness C; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Madlock-Brown C; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Suver C; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Chute C; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Dillon C; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Wu C; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Schmitt C; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Takemoto C; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Housman D; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Gabriel D; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Eichmann DA; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Mazzotti D; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Brown D; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Boudreau E; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Hill E; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Zampino E; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Marti EC; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Pfaff ER; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • French E; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Koraishy FM; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Mariona F; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Prior F; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Sokos G; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Martin G; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Lehmann H; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
  • Spratt H; Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
  • Mehta H; Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.
Otol Neurotol Open ; 4(2): e051, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38919767
ABSTRACT

Objective:

Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population. Study

Design:

Retrospective.

Setting:

Clinical data in the National COVID Cohort Collaborative database (N3C).

Methods:

Deidentified patient data from the National COVID Cohort Collaborative database (N3C) were queried based on variant peak prevalence (untyped, alpha, delta, omicron 21K, and omicron 23A) from covariants.org to retrospectively analyze the incidence of vestibular disorders in patients with SARS-CoV-2 compared to control population, consisting of patients without documented evidence of COVID infection during the same period.

Results:

Patients testing positive for COVID-19 were significantly more likely to have a vestibular disorder compared to the control population. Compared to control patients, the odds ratio of vestibular disorders was significantly elevated in patients with untyped (odds ratio [OR], 2.39; confidence intervals [CI], 2.29-2.50; P < 0.001), alpha (OR, 3.63; CI, 3.48-3.78; P < 0.001), delta (OR, 3.03; CI, 2.94-3.12; P < 0.001), omicron 21K variant (OR, 2.97; CI, 2.90-3.04; P < 0.001), and omicron 23A variant (OR, 8.80; CI, 8.35-9.27; P < 0.001).

Conclusions:

The incidence of vestibular disorders differed between COVID-19 variants and was significantly elevated in COVID-19-positive patients compared to the control population. These findings have implications for patient counseling and further research is needed to discern the long-term effects of these findings.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Otol Neurotol Open Year: 2024 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Otol Neurotol Open Year: 2024 Document type: Article Country of publication: