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Unraveling the propensity of various genetic disorders and syndromes in the Koraga, an aboriginal tribe from southern India.
Krishna, Swathy M; Prabhu, Suneetha M; DAS, Ranajit.
Affiliation
  • Krishna SM; Division of Data Analytics, Bioinformatics and Structural Biology (DABS), Yenepoya Research Centre (YRC), Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore 575018, India.
J Biosci ; 492024.
Article in En | MEDLINE | ID: mdl-38920107
ABSTRACT
Koragas, recognized as a particularly vulnerable tribal group (PVTG) by the Government of India, are from coastal Karnataka and Kerala. They are experiencing severe socioeconomic and health-related issues and rapid depopulation. The unique genetic makeup of Koragas has been maintained by the practice of endogamy. We aimed to identify genetic factors potentially associated with the predisposition of Koragas towards genetic and multifactorial disorders. We employed genome-wise data of 29 Koraga individuals genotyped on the Infinium Global Screening Array-24 v3.0 BeadChip platform and performed various population genetic analyses including kinship, identity by descent (IBD), and runs of homozygosity (RoH). A high degree of haplotype sharing among the Koraga participants may be indicative of a recent founder event. We identified genetic variants and genes associated with several genetic disorders, higher infant mortality rate, neurological disorders, deafness, and lower fertility rate of this agrarian tribe. Ours is the first genome-wide study on the Koraga tribe that identified genetic factors associated with various genetic disorders. Our findings can provide public healthcare providers with essential genetic information that can be useful in augmenting medical and healthcare services and improving the quality of life of Koragas.
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Collection: 01-internacional Database: MEDLINE Main subject: Haplotypes / Genetic Predisposition to Disease Limits: Adult / Female / Humans / Infant / Male Country/Region as subject: Asia Language: En Journal: J Biosci Year: 2024 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Haplotypes / Genetic Predisposition to Disease Limits: Adult / Female / Humans / Infant / Male Country/Region as subject: Asia Language: En Journal: J Biosci Year: 2024 Document type: Article Affiliation country: Country of publication: