The association of smoking on the increased risk of osteoporotic fracture: Results from a cross-sectional study and two-sample Mendelian randomization.
Tob Induc Dis
; 222024.
Article
in En
| MEDLINE
| ID: mdl-38933524
ABSTRACT
INTRODUCTION:
We conducted analyses of the association between smoking and osteoporosis and osteoporotic fractures using a secondary dataset analysis of the National Health and Nutrition Examination Survey (NHANES) database and the two-sample Mendelian randomization (MR) method.METHODS:
The associations between smoking and osteoporosis or osteoporotic fractures were analyzed using weighted logistic regression models for both univariate and multivariable analyses using pooled 1999-2018 NHANES data. The summary-level data of genome-wide association studies (GWAS) of smoking and osteoporosis were extracted from the IEU Open GWAS project. The inverse variance weighted method was used as the main method for the two-sample MR analysis.RESULTS:
We obtained the following main findings based on the NHANES data smoking was associated with osteoporosis according to the analyses of 30856 participants (OR=1.21; 95% CI 1.06-1.39, p=0.004); smoking was associated with hip osteoporotic fracture according to the analyses of 30928 participants (OR=1.47; 95% CI 1.14-1.90, p=0.004); smoking was associated with wrist osteoporotic fracture according to the analyses of 30923 participants (OR=1.33; 95% CI 1.18-1.49, p<0.001); and smoking was associated with spine osteoporotic fracture according to the analyses of 30910 participants (OR=1.43, 95% CI 1.18-1.73, p<0.001). In addition, we confirmed the potential causal effect of smoking on the risk of osteoporotic fracture (OR=24.5; 95% CI 1.11-539, p=0.043) by conducting two-sample MR analyses.CONCLUSIONS:
Smoking was associated with increased risks of both osteoporosis and osteoporotic fracture. Smoking showed a potential causal effect on the risk of osteoporotic fracture.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Tob Induc Dis
Year:
2024
Document type:
Article
Affiliation country:
Publication country:
GR
/
GRECIA
/
GREECE
/
GRÉCIA