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Millettia dubia De Wild. (Fabaceae): Structural analysis of the oleanane-type glycosides and stimulation of the sweet taste receptors TAS1R2/TAS1R3.
Pertuit, David; Belloir, Christine; Bouizi, Younes; Delaude, Clément; Kapundu, Mpuza; Lacaille-Dubois, Marie-Aleth; Briand, Loïc; Mitaine-Offer, Anne-Claire.
Affiliation
  • Pertuit D; Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France.
  • Belloir C; Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France.
  • Bouizi Y; CRM2 (UMR UL-CNRS 7036), Faculté des Sciences et Technologies, Université de Lorraine, BP 70239, 54506, Vandoeuvre-lès-Nancy Cedex, France.
  • Delaude C; Centre de Recherche Phytochimique, Université de Liège, Institut de Chimie B-6, Sart Tilman, B-4000, Liège I, Belgium.
  • Kapundu M; Centre D'Études des Substances Naturelles D'Origine Végétale, Faculté des Sciences Pharmaceutiques, Université de Kinshasa, Democratic Republic of the Congo.
  • Lacaille-Dubois MA; Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France.
  • Briand L; Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France.
  • Mitaine-Offer AC; Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France. Electronic address: anne-claire.offer@u-bourgogne.fr.
Phytochemistry ; 226: 114204, 2024 Oct.
Article in En | MEDLINE | ID: mdl-38971498
ABSTRACT
From the root barks of a Central African tree Millettia dubia De Wild. (Fabaceae), ten previously undescribed oleanane-type glycosides were isolated by various chromatographic protocols. Their structures were elucidated by spectroscopic methods, mainly 2D NMR experiments and mass spectrometry, as mono- and bidesmosidic glycosides of mesembryanthemoidigenic acid, hederagenin and oleanolic acid. The stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated, and structure/activity relationships were proposed. Two of them showed an agonist effect on TAS1R2/TAS1R3.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Receptors, G-Protein-Coupled / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Receptors, G-Protein-Coupled / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2024 Document type: Article Affiliation country: Country of publication: