SMARCB1/INI1-deficient undifferentiated tumour of the thorax: a case report and review of the literature.
Pathologica
; 116(3): 163-169, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38979590
ABSTRACT
The 5th WHO classification of thoracic tumours includes thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-UT) among the "other epithelial tumours of the lung" chapter. Herein, we present a case of undifferentiated thoracic neoplasm with retention of SMARCA4 expression, lack of NUT fusion protein and loss of SMARCB1/INI1 expression. After presenting the clinical and pathological features of the tumour, we carried out a review of the literature on the same topic. Albeit very rare, we believe this entity should be included in the heterogeneous group of undifferentiated neoplasms of the thorax.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thoracic Neoplasms
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Transcription Factors
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DNA Helicases
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SMARCB1 Protein
Limits:
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Pathologica
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: