Risk of map-like redness development after eradication therapy for Helicobacter pylori infection.
Helicobacter
; 29(1): e13046, 2024.
Article
in En
| MEDLINE
| ID: mdl-38984721
ABSTRACT
BACKGROUND:
Map-like redness is a newly identified endoscopic risk factor for gastric cancer in patients who received Helicobacter pylori eradication therapy. However, the incidence rate of map-like redness in patients who received eradication, and the risk factors for the development of map-like redness remain unclear. We hence aimed to investigate the incidence rate of map-like redness at 1-year post H. pylori eradication, and evaluated its associations with map-like redness and gastric cancer in relation with gastric condition. MATERIALS ANDMETHODS:
Endoscopic severity of gastritis and map-like redness were retrospectively evaluated according to the Kyoto Classification of Gastritis in patients who had undergone endoscopy before and after H. pylori eradication therapy.RESULTS:
The incidence rate of map-like redness for all 328 patients at a mean of 1.2 ± 0.6 years after eradication was 25.3% (95% confidence interval [CI] 20.7%-30.4%). Patients who developed map-like redness were older, had more severe atrophy and intestinal metaplasia, a higher total score of the Kyoto Classification of Gastritis both before and after eradication, and a higher rate of gastric cancer history than patients who did not have map-like redness. On multivariate analysis, risk of map-like redness was increased in patients with intestinal metaplasia (odds ratio [OR] 2.794, 95% CI 1.155-6.757) and taking acid inhibitors (OR 1.948, 95% CI 1.070-3.547). Characteristics of H. pylori-positive patients with gastric cancer history were patients who were older (OR 1.033, 95% CI 1.001-1.066), taking acid inhibitors (OR 4.456, 95% CI 2.340-8.484), and with occurrence of map-like redness after eradication therapy (OR 2.432, 95% CI 1.264-4.679).CONCLUSIONS:
Map-like redness is observed in one fourth of patients at 1-year post eradication. Patients who developed map-like redness were found to have severe intestinal metaplasia and taking acid inhibitors, and hence such patients require increased attention at surveillance endoscopy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Helicobacter pylori
/
Helicobacter Infections
/
Gastritis
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Helicobacter
Journal subject:
BACTERIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: