Mechanisms of resistance to trastuzumab in HER2-positive gastric cancer.
Chin J Cancer Res
; 36(3): 306-321, 2024 Jun 30.
Article
in En
| MEDLINE
| ID: mdl-38988489
ABSTRACT
Gastric cancer is one of the most prevalent cancers worldwide, and human epidermal growth factor receptor 2 (HER2)-positive cases account for approximately 20% of the total cases. Currently, trastuzumab + chemotherapy is the recommended first-line treatment for patients with HER2-positive advanced gastric cancer, and the combination has exhibited definite efficacy in HER2-targeted therapy. However, the emergence of drug resistance during treatment considerably reduces its effectiveness; thus, it is imperative to investigate the potential mechanisms underlying resistance. In the present review article, we comprehensively introduce multiple mechanisms underlying resistance to trastuzumab in HER2-positive gastric cancer cases, aiming to provide insights for rectifying issues associated with resistance to trastuzumab and devising subsequent treatment strategies.
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01-internacional
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MEDLINE
Language:
En
Journal:
Chin J Cancer Res
Year:
2024
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Article
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