White matter substrates underlying morphological awareness deficit in Chinese children with developmental dyslexia.
Prog Neuropsychopharmacol Biol Psychiatry
; 134: 111083, 2024 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-38992486
ABSTRACT
BACKGROUND:
Morphological awareness (MA) deficit is strongly associated with Chinese developmental dyslexia (DD). However, little is known about the white matter substrates underlying the MA deficit in Chinese children with DD.METHODS:
In the current study, 34 Chinese children with DD and 42 typical developmental (TD) children were recruited to complete a diffusion magnetic resonance imaging scan and cognitive tests for MA. We conducted linear regression to test the correlation between MA and DTI metrics, the structural abnormalities of the tracts related to MA, and the interaction effect of DTI metrics by group on MA.RESULTS:
First, MA was significant related to the right inferior occipito-frontal fascicle (IFO) and inferior longitudinal fsciculus (ILF), the bilateral thalamo-occipital (T_OCC) and the left arcuate fasciculus (AF); second, compared to TD children, Chinese children with DD had lower axial diffusivity (AD) in the right IFO and T_OCC; third, there were significant interactions between metrics (fractional anisotropy (FA) and radial diffusivity (RD)) of the right IFO and MA in groups. The FA and RD of the right IFO were significantly associated with MA in children with DD but not in TD children.CONCLUSION:
In conclusion, compared to TD children, Chinese children with DD had axonal degeneration not only in the ventral tract (the right IFO) but also the visuospatial tract (the right T_OCC) which were associated with their MA deficit. And Chinese MA involved not only the ventral tracts, but also the visuospatial pathway and dorsal tracts.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dyslexia
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Diffusion Tensor Imaging
/
White Matter
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Prog Neuropsychopharmacol Biol Psychiatry
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: