Toxoplasma gondii infection supports the infiltration of T cells into brain tumors.
J Neuroimmunol
; 393: 578402, 2024 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-38996717
ABSTRACT
Few T cells infiltrate into primary brain tumors, fundamentally hampering the effectiveness of immunotherapy. We hypothesized that Toxoplasma gondii, a microorganism that naturally elicits a Th1 response in the brain, can promote T cell infiltration into brain tumors despite their immune suppressive microenvironment. Using a mouse genetic model for medulloblastoma, we found that T. gondii infection induced the infiltration of activatable T cells into the tumor mass and led to myeloid cell reprogramming toward a T cell-supportive state, without causing severe health issues in mice. The study provides a concrete foundation for future studies to take advantage of the immune modulatory capacity of T. gondii to facilitate brain tumor immunotherapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Toxoplasmosis
Limits:
Animals
Language:
En
Journal:
J Neuroimmunol
Year:
2024
Document type:
Article
Affiliation country: