Your browser doesn't support javascript.
loading
Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress.
Kolodeeva, O E; Kolodeeva, O E; Averinskaya, D A; Makarova, Yu A.
Affiliation
  • Kolodeeva OE; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. oekolodeeva@hse.ru.
  • Kolodeeva OE; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. okolodeeva@hse.ru.
  • Averinskaya DA; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. daverinskaya@hse.ru.
  • Makarova YA; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. jmakarova@hse.ru.
Dokl Biochem Biophys ; 517(1): 264-268, 2024 Aug.
Article in En | MEDLINE | ID: mdl-39002013
ABSTRACT
Translation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line was investigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysis revealed that viscumin induces the ER stress activated by the PERK sensor.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Eukaryotic Initiation Factor-2 / EIF-2 Kinase / Activating Transcription Factor 4 / Endoplasmic Reticulum Stress / Macrophages Limits: Humans Language: En Journal: Dokl Biochem Biophys Journal subject: BIOFISICA / BIOQUIMICA Year: 2024 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Eukaryotic Initiation Factor-2 / EIF-2 Kinase / Activating Transcription Factor 4 / Endoplasmic Reticulum Stress / Macrophages Limits: Humans Language: En Journal: Dokl Biochem Biophys Journal subject: BIOFISICA / BIOQUIMICA Year: 2024 Document type: Article Affiliation country: