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Design and in vitro evaluation of 223Ra/99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy.
Wang, Yumei; Zhou, Yue; Zhai, Dongliang; Deng, Hao; Chen, Xiaoliang.
Affiliation
  • Wang Y; Department of Nuclear Medicine, Chongqing University Cancer Hospital, No 181 HanYu St, Shapingba District 400030, P.R. China.
  • Zhou Y; Department of Nuclear Medicine, Chongqing University Cancer Hospital, No 181 HanYu St, Shapingba District 400030, P.R. China.
  • Zhai D; Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing 100037, China.
  • Deng H; Department of Nuclear Medicine, Chongqing University Cancer Hospital, No 181 HanYu St, Shapingba District 400030, P.R. China.
  • Chen X; Department of Nuclear Medicine, Chongqing University Cancer Hospital, No 181 HanYu St, Shapingba District 400030, P.R. China.
Nanomedicine (Lond) ; 19(17): 1557-1567, 2024 Jul 14.
Article in En | MEDLINE | ID: mdl-39011932
ABSTRACT

Aim:

Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific activity (sp.act.) of 223Ra@nHA limits its application in medicine.

Methods:

We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of 223Ra@nHA and a new method to loaded 99mTc for in vivo tracking.

Results:

The nHA synthesized using PEG as a template was associated with higher sp.act for 223Ra in comparison to nHA with identical particle size and without PEG. The nHA load 99mTc-MDP was associated with higher labeling rate and stability in comparison to 99mTc.

Conclusion:

All these findings suggest that using PEG as a template and 99mTc-MDP could be the most effective of synthetic 223Ra/99mTc@nHA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Bone Neoplasms / Radium / Durapatite Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Bone Neoplasms / Radium / Durapatite Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2024 Document type: Article