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Antibody Response to Symptomatic Infection With SARS-CoV-2 Omicron Variant Viruses, December 2021-June 2022.
Sandford, Ryan; Yadav, Ruchi; Noble, Emma K; Sumner, Kelsey; Joshi, Devyani; Tartof, Sara Y; Wernli, Karen J; Martin, Emily T; Gaglani, Manjusha; Zimmerman, Richard K; Talbot, H Keipp; Grijalva, Carlos G; Belongia, Edward A; Carlson, Christina; Coughlin, Melissa; Flannery, Brendan; Pearce, Brad; Rogier, Eric.
Affiliation
  • Sandford R; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Yadav R; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA.
  • Noble EK; Rollins School of Public Health, Atlanta, Georgia, USA.
  • Sumner K; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Joshi D; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tartof SY; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA.
  • Wernli KJ; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Martin ET; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gaglani M; Department of Research & Evaluation, Kaiser Permanente Southern California, Yorba Linda, California, USA.
  • Zimmerman RK; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California, USA.
  • Talbot HK; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
  • Grijalva CG; University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Belongia EA; Baylor Scott & White Health, Temple, Texas, USA.
  • Carlson C; Texas A&M University College of Medicine, Temple, Texas, USA.
  • Coughlin M; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Flannery B; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Pearce B; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Rogier E; Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Influenza Other Respir Viruses ; 18(7): e13339, 2024 Jul.
Article in En | MEDLINE | ID: mdl-39012045
ABSTRACT
We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Influenza Other Respir Viruses Journal subject: VIROLOGIA Year: 2024 Document type: Article Affiliation country: Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Influenza Other Respir Viruses Journal subject: VIROLOGIA Year: 2024 Document type: Article Affiliation country: Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM