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Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort.
Jacquin, Nicolas; Flippot, Ronan; Masliah-Planchon, Julien; Grisay, Guillaume; Brillet, Riwan; Dupain, Célia; Kamal, Maud; Guillou, Isabelle; Gruel, Nadège; Servant, Nicolas; Gestraud, Pierre; Wong, Jennifer; Cockenpot, Vincent; Goncalves, Andreia; Selves, Janick; Blons, Hélène; Rouleau, Etienne; Delattre, Olivier; Gervais, Claire; Le Tourneau, Christophe; Bièche, Ivan; Allory, Yves; Albigès, Laurence; Watson, Sarah.
Affiliation
  • Jacquin N; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.
  • Flippot R; Department of Medical Oncology, Institut Godinot, Reims, France.
  • Masliah-Planchon J; Department of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Grisay G; Somatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France.
  • Brillet R; Department of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Dupain C; Clinical Bioinformatic Unit, Department of Diagnostic and Theragnostic Medicine, Institut Curie Hospital, Paris, France.
  • Kamal M; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Guillou I; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Gruel N; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Servant N; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.
  • Gestraud P; Department of Translational Research, Institut Curie Hospital, Paris, France.
  • Wong J; INSERM U900, CBIO-Centre for Computational Biology, Institut Curie Research Center, Mines ParisTech, Paris, France.
  • Cockenpot V; INSERM U900, CBIO-Centre for Computational Biology, Institut Curie Research Center, Mines ParisTech, Paris, France.
  • Goncalves A; Somatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France.
  • Selves J; Department of Pathology, Institut Curie Hospital, Paris, France.
  • Blons H; Department of Pathology, Institut Curie Hospital, Paris, France.
  • Rouleau E; Department of Pathology, University Hospital of Toulouse (IUCT), Toulouse, France.
  • Delattre O; Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, APHP, Paris, France.
  • Gervais C; PRISM Center for personalized medicine, Gustave Roussy Cancer Center, Villejuif, France.
  • Le Tourneau C; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.
  • Bièche I; Somatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France.
  • Allory Y; Department of Medical Oncology, Georges Pompidou European Hospital, APHP, Paris, France.
  • Albigès L; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Watson S; INSERM U900, Institut Curie, Saint-Cloud, France.
NPJ Precis Oncol ; 8(1): 147, 2024 Jul 18.
Article in En | MEDLINE | ID: mdl-39025947
ABSTRACT
Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Precis Oncol Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Precis Oncol Year: 2024 Document type: Article Affiliation country: Country of publication: