The role of novel protein acylations in cancer.
Eur J Pharmacol
; 979: 176841, 2024 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-39033839
ABSTRACT
Novel protein acylations are a class of protein post-translational modifications, such as lactylation, succinylation, crotonylation, palmitoylation, and ß-hydroxybutyrylation. These acylation modifications are common in prokaryotes and eukaryotes and play pivotal roles in various key cellular processes by regulating gene transcription, protein subcellular localization, stability and activity, protein-protein interactions, and protein-DNA interactions. The diversified acylations are closely associated with various human diseases, especially cancer. In this review, we provide an overview of the distinctive characteristics, effects, and regulatory factors of novel protein acylations. We also explore the various mechanisms through which novel protein acylations are involved in the occurrence and progression of cancer. Furthermore, we discuss the development of anti-cancer drugs targeting novel acylations, offering promising avenues for cancer treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Processing, Post-Translational
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Neoplasms
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Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Eur J Pharmacol
Year:
2024
Document type:
Article
Affiliation country: