Primary palatal sarcoma exhibiting EWSR1::RORß fusion: a first case report and literature review.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 2024 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-39069454
ABSTRACT
In this report, a tumor exhibited EWSR1RORß gene fusion, to our knowledge, is the first such reported case. The Ewing sarcoma breakpoint region 1 gene (EWSR1) is known to be associated with several soft tissue tumors although its specific role remains unclear. Its fusion with a member of the ETS family, including FLI1 and ERG, results in Ewing sarcoma, and its fusion with other genes unrelated to the ETS family, including NFATC2 and PATZ1, results in round cell sarcoma with EWSR1-non-ETS fusions, previously referred to as Ewing-like sarcoma. RORß encodes retinoic acid-related orphan receptor ß, a nuclear receptor (NR), and is involved in circadian rhythm modulation and cancer regulation. The specific role of RORß in tumorigenesis remains unclear; however, this case report suggests that it may form part of a new tumorigenic entity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Oral Surg Oral Med Oral Pathol Oral Radiol
Year:
2024
Document type:
Article