The utility of obesity polygenic risk scores from research to clinical practice: A review.
Obes Rev
; 25(11): e13810, 2024 Nov.
Article
in En
| MEDLINE
| ID: mdl-39075585
ABSTRACT
Obesity represents a major public health emergency worldwide, and its etiology is shaped by a complex interplay of environmental and genetic factors. Over the last decade, polygenic risk scores (PRS) have emerged as a promising tool to quantify an individual's genetic risk of obesity. The field of PRS in obesity genetics is rapidly evolving, shedding new lights on obesity mechanisms and holding promise for contributing to personalized prevention and treatment. Challenges persist in terms of its clinical integration, including the need for further validation in large-scale prospective cohorts, ethical considerations, and implications for health disparities. In this review, we provide a comprehensive overview of PRS for studying the genetics of obesity, spanning from methodological nuances to clinical applications and challenges. We summarize the latest developments in the generation and refinement of PRS for obesity, including advances in methodologies for aggregating genome-wide association study data and improving PRS predictive accuracy, and discuss limitations that need to be overcome to fully realize its potential benefits of PRS in both medicine and public health.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Predisposition to Disease
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Multifactorial Inheritance
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Genome-Wide Association Study
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Obesity
Limits:
Humans
Language:
En
Journal:
Obes Rev
Journal subject:
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: