Drug-induced hepatotoxicity and association with slow acetylation variants NAT2*5 and NAT2*6 in Cameroonian patients with tuberculosis and HIV co-infection.
BMC Infect Dis
; 24(1): 759, 2024 Jul 31.
Article
in En
| MEDLINE
| ID: mdl-39085767
ABSTRACT
BACKGROUND:
Human immunodeficiency virus (HIV) and tuberculosis (TB) are major contributors to morbidity and mortality in sub-Saharan Africa including Cameroon. Pharmacogenetic variants could serve as predictors of drug-induced hepatotoxicity (DIH), in patients with TB co-infected with HIV. We evaluated the occurrence of DIH and pharmacogenetic variants in Cameroonian patients.METHODS:
Treatment-naïve patients with HIV, TB or TB/HIV co-infection were recruited at three hospitals in Cameroon, between September 2018 and November 2019. Appropriate treatment was initiated, and patients followed up for 12 weeks to assess DIH. Pharmacogenetic variants were assessed by allele discrimination TaqMan SNP assays.RESULTS:
Of the 141 treatment naïve patients, the overall incidence of DIH was 38% (53/141). The highest incidence of DIH, 52% (32/61), was observed among HIV patients. Of 32 pharmacogenetic variants, the slow acetylation variants NAT2*5 was associated with a decreased risk of DIH (OR 0.4; 95%CI 0.17-0.96; p = 0.038), while NAT2*6 was found to be associated with an increased risk of DIH (OR 4.2; 95%CI 1.1-15.2; p = 0.017) among patients treated for TB. Up to 15 SNPs differed in ≥ 5% of allele frequencies among African populations, while 25 SNPs differed in ≥ 5% of the allele frequencies among non-African populations, respectively.CONCLUSIONS:
DIH is an important clinical problem in African patients with TB and HIV. The NAT2*5 and NAT2*6 variants were found to be associated with DIH in the Cameroonian population. Prior screening for the slow acetylation variants NAT2*5 and NAT2*6 may prevent DIH in TB and HIV-coinfected patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arylamine N-Acetyltransferase
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Tuberculosis
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HIV Infections
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Chemical and Drug Induced Liver Injury
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Coinfection
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Antitubercular Agents
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Country/Region as subject:
Africa
Language:
En
Journal:
BMC Infect Dis
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BMC infect. dis
/
BMC infectious diseases
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: