Lewis Acid-Driven Multicomponent Reactions Enable 2-Alkyl Chromanones with Anticancer Activities.
J Org Chem
; 89(16): 11671-11681, 2024 08 16.
Article
in En
| MEDLINE
| ID: mdl-39096319
ABSTRACT
2-Alkyl chromanone scaffold has become prominent in pharmaceuticals and natural compounds. Consequently, devising robust strategies for synthesizing 2-alkyl chromanones remains crucial. Here, multicomponent reactions were employed to synthesize 2-alkyl chromanones containing an oxazole moiety using 3-formylchromones, amines, and N-propargylamides as reactants. This method utilizes readily available feedstocks with a catalytic amount of Zn(OTf)2 and exhibits an impressive substrate scope compared to existing methods. Importantly, the synthesized compounds demonstrated highly selective anticancer activity against the DU145 cell line.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromones
/
Lewis Acids
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
J Org Chem
/
J. org. chem
/
Journal of organic chemistry
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: