Associations between brain structures, cognition and dual-task performance in patients with mild cognitive impairment: A study based on voxel-based morphology.
Hum Mov Sci
; 97: 103257, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39126810
ABSTRACT
BACKGROUND:
This study aimed to explore the associations between brain structures, cognition, and motor control in participants with mild cognitive impairment (MCI), with a focus on dual-task performance.METHODS:
Thirty MCI patients and thirty healthy controls were enrolled. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Structural magnetic resonance imaging data were analyzed using voxel-based morphometry (VBM) to calculate brain parenchyma volume and gray matter volume (GMV). Participants performed single- and dual-task Timed Up and Go (TUG) tests, and the correlations between significant GMV differences and task execution time was analyzed.RESULTS:
MCI patients showed significantly lower MoCA scores, particularly in visuospatial/executive, attention, and delayed recall domains (p < 0.05). Dual-task TUG execution time was significantly increased in MCI patients (p < 0.05). The GMV in the right anterior lobe of the cerebellum and both insulae was positively correlated with visuospatial/executive scores (FDR-corrected, p < 0.05). The GMV of the right cerebellar anterior lobe and insula were significantly reduced in MCI patients (p < 0.05). The GMV of the right cerebellar anterior lobe was negatively correlated with dual-task execution time (r = -0.32, p = 0.012).CONCLUSION:
Smaller GMV in the right anterior lobe of the cerebellum was associated with impaired dual-task performance, which may provide more evidence for the neural mechanisms of cognitive and motor function impairments in MCI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
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Magnetic Resonance Imaging
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Cognition
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Cognitive Dysfunction
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Hum Mov Sci
Year:
2024
Document type:
Article
Country of publication: