B(C6F5)3-Catalyzed Multicomponent Reactions of 2,3-Diketoesters, Amines, Allenes, and Nucleophiles: Synthesis of 2α-Functionalized Pyrroles.
J Org Chem
; 89(17): 12286-12297, 2024 Sep 06.
Article
in En
| MEDLINE
| ID: mdl-39146254
ABSTRACT
An efficient B(C6F5)3-catalyzed multicomponent reaction of 2,3-diketoesters, amines, allenes, and nucleophiles was reported, which afforded 2α-functionalized pyrroles in moderate to good yields. The reaction features low catalyst loading, usage of a small amount of solvent, high atom economy, tunable installation of diverse functional groups at 2α-position, and water being formed as the byproduct. This is the first multicomponent reaction that combines vicinal tricarbonyl compounds with allenes.
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01-internacional
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MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2024
Document type:
Article
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