Immune-related Adverse Event with Checkpoint Inhibitors Might Be an Emerging Underlying Disease of Steroid-related Osteonecrosis of the Femoral Head: A Case Report.
J Orthop Case Rep
; 14(8): 36-41, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39157500
ABSTRACT
Introduction:
Immune checkpoint inhibitors (ICIs) are increasingly being used in the treatment of advanced metastatic and immunogenic cancers. However, these therapies could cause immune-related adverse events (irAEs), which require high-dose glucocorticoid administration. Case Report A 52-year-old man with metastatic renal cell carcinoma received ICI therapy. Two weeks later, he suffered from severe irAEs and received glucocorticoid therapy for 13 months. Twenty-one months after the initiation of glucocorticoid administration, he presented to us with bilateral hip pain and was diagnosed with bilateral osteonecrosis of the femoral head (ONFH).Conclusion:
IrAEs associated with ICI therapy might be an emerging underlying disease of ONFH.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Orthop Case Rep
Year:
2024
Document type:
Article
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