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The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes.
Carciero, Lorenzo; Di Giuseppe, Gianfranco; Di Piazza, Eleonora; Parand, Erfan; Soldovieri, Laura; Ciccarelli, Gea; Brunetti, Michela; Gasbarrini, Antonio; Nista, Enrico C; Pani, Giovambattista; Pontecorvi, Alfredo; Giaccari, Andrea; Mezza, Teresa.
Affiliation
  • Carciero L; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
  • Di Giuseppe G; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Di Piazza E; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Parand E; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Soldovieri L; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Ciccarelli G; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Brunetti M; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Gasbarrini A; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
  • Nista EC; Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
  • Pani G; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
  • Pontecorvi A; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Giaccari A; Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Mezza T; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy. Electronic address: teresa.mezza@unicatt.
Diabetes Res Clin Pract ; 216: 111837, 2024 Aug 21.
Article in En | MEDLINE | ID: mdl-39173679
ABSTRACT
The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and ß cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Diabetes Res Clin Pract Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Diabetes Res Clin Pract Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: