Antiphospholipid antibody testing.
Med Clin (Barc)
; 163 Suppl 1: S4-S9, 2024 08.
Article
in En, Es
| MEDLINE
| ID: mdl-39174152
ABSTRACT
Antiphospholipid antibodies (aPL) are a family of autoantibodies targeting phospholipid-binding proteins and are associated with several clinical settings, and most notably define the antiphospholipid syndrome (APS). These antibodies can be identified using a variety of laboratory tests, which include both solid-phase immunological assays and functional clotting assays that detect lupus anticoagulants (LA). aPLs are linked to a range of adverse medical conditions, such as thrombosis and complications affecting the placenta and fetus, potentially leading to morbidity and mortality. The specific aPL identified, along with the pattern of reactivity, correlates with the severity of these conditions. Therefore, laboratory testing for aPL is crucial for evaluating the risk of complications and for fulfilling certain classification criteria for APS, which are also applied as diagnostic markers in medical practice. This review provides an overview of the available laboratory tests currently for measuring aPL and discusses their clinical implications.
Key words
Anti-beta-2 glycoprotein I antibodies; Anticardiolipin antibodies; Anticoagulante lúpico; Anticuerpo antifosfolípido; Anticuerpos anti-beta-2 glicoproteína I; Anticuerpos anticardiolipina; Antiphospholipid antibody; Antiphospholipid antibody testing; Lupus anticoagulant; Pruebas de anticuerpos antifosfolípidos
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiphospholipid Syndrome
/
Antibodies, Antiphospholipid
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
/
Es
Journal:
Med Clin (Barc)
Year:
2024
Document type:
Article
Country of publication: