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Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson, Kristjan H; Abini-Agbomson, Stephen; Gloor, Susan L; Weinberg, Daniel N; McCuiston, Jamie L; Kumary, Vishnu Udayakumar Sunitha; Hickman, Allison R; Sahu, Varun; Lee, Rachel; Xu, Xinjing; Lipieta, Natalie; Flashner, Samuel; Adeleke, Oluwatobi A; Popova, Irina K; Taylor, Hailey F; Noll, Kelsey; Windham, Carolina Lin; Maryanski, Danielle N; Venters, Bryan J; Nakagawa, Hiroshi; Keogh, Michael-Christopher; Armache, Karim-Jean; Lu, Chao.
Affiliation
  • Gretarsson KH; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Abini-Agbomson S; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Gloor SL; EpiCypher Inc., Durham, NC 27709, USA.
  • Weinberg DN; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  • McCuiston JL; EpiCypher Inc., Durham, NC 27709, USA.
  • Kumary VUS; EpiCypher Inc., Durham, NC 27709, USA.
  • Hickman AR; EpiCypher Inc., Durham, NC 27709, USA.
  • Sahu V; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Lee R; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Xu X; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Lipieta N; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Flashner S; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA.
  • Adeleke OA; EpiCypher Inc., Durham, NC 27709, USA.
  • Popova IK; EpiCypher Inc., Durham, NC 27709, USA.
  • Taylor HF; EpiCypher Inc., Durham, NC 27709, USA.
  • Noll K; EpiCypher Inc., Durham, NC 27709, USA.
  • Windham CL; EpiCypher Inc., Durham, NC 27709, USA.
  • Maryanski DN; EpiCypher Inc., Durham, NC 27709, USA.
  • Venters BJ; EpiCypher Inc., Durham, NC 27709, USA.
  • Nakagawa H; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA.
  • Keogh MC; EpiCypher Inc., Durham, NC 27709, USA.
  • Armache KJ; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Lu C; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sci Adv ; 10(35): eadp0975, 2024 Aug 30.
Article in En | MEDLINE | ID: mdl-39196936
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Binding / Histones / Nucleosomes / CpG Islands / DNA Methylation / DNA (Cytosine-5-)-Methyltransferases / Ubiquitination / DNA Methyltransferase 3A / Neoplasms Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Binding / Histones / Nucleosomes / CpG Islands / DNA Methylation / DNA (Cytosine-5-)-Methyltransferases / Ubiquitination / DNA Methyltransferase 3A / Neoplasms Limits: Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article Affiliation country: Country of publication: