Modulation of electroencephalogram brain activity dynamics by 10â¯Hz parietal repetitive transcranial magnetic stimulation: Implications for recovery of the minimally conscious state.
Neurosci Lett
; : 137986, 2024 Sep 09.
Article
in En
| MEDLINE
| ID: mdl-39260738
ABSTRACT
BACKGROUND AND OBJECTIVES:
Despite the fact that the parietal cortex is associated with consciousness, the underlying mechanisms of parietal repetitive transcranial magnetic stimulation (rTMS) have not yet been specifically investigated. The present study aims to examine the effects of parietal rTMS on patients with disorders of consciousness (DoC) and identify a novel potential target.METHODS:
Twenty minimally conscious state (MCS) patients were stochastically assigned to a real or sham rTMS group in a controlled trial. The real rTMS group was administered over the parietal cortex, with a frequency of 10â¯Hz and a rest motor threshold of 90â¯%. The sham rTMS group was identical to the real rTMS group without magnetic stimulation over the cortex. Pre- and post-treatment resting-state electrophysiological (EEG) data and coma recovery scale-revised (CRS-R) score were gathered. Microstate analyses were calculated to evaluate the brain activity dynamics.RESULTS:
The real rTMS treatment improved the CRS-R scores. There were notable alterations in the mean microstate duration (MMD) of microstate B in the real rTMS group. The sham rTMS group did not exhibit such changes in CRS-R score or EEG results, which were not statistically significant. Furthermore, the MMD and RTC of microstate E were found to be negatively correlated with baseline CRS-R scores.CONCLUSION:
Parietal rTMS can induce behavioral improvement and brain activity dynamics in patients with MCS. EEG microstates can be used as a valuable method to study neurophysiological mechanisms behind MCS. And the parietal cortex represents an alternative for rTMS therapy protocols.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Neurosci Lett
Year:
2024
Document type:
Article
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