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Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.
Hodgson, J E; Fosberry, A P; Rawlinson, N S; Ross, H N; Neal, R J; Arnell, J C; Earl, A J; Lawlor, E J.
Affiliation
  • Hodgson JE; SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
Gene ; 166(1): 49-55, 1995 Dec 01.
Article in En | MEDLINE | ID: mdl-8529893
ABSTRACT
Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.
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Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus / Clavulanic Acids / Anti-Bacterial Agents Language: En Journal: Gene Year: 1995 Document type: Article Affiliation country:
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus / Clavulanic Acids / Anti-Bacterial Agents Language: En Journal: Gene Year: 1995 Document type: Article Affiliation country: