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Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
Reen, R K; Roesch, S F; Kiefer, F; Wiebel, F J; Singh, J.
Affiliation
  • Reen RK; Biochemistry Section, Regional Research Laboratory (CSIR), Jammu Tawi, India.
Biochem Biophys Res Commun ; 218(2): 562-9, 1996 Jan 17.
Article in En | MEDLINE | ID: mdl-8561796
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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Alkaloids / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 1996 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Alkaloids / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 1996 Document type: Article Affiliation country: Country of publication: