Structural and serological studies of the O-specific polysaccharide of the bacterium Proteus mirabilis O10 containing L-altruronic acid, a new component of O-antigens.
FEBS Lett
; 398(2-3): 297-302, 1996 Dec 02.
Article
in En
| MEDLINE
| ID: mdl-8977126
ABSTRACT
An acidic O-specific polysaccharide from the lipopolysaccharide of Proteus mirabilis O10 contains 2-acetamido-2-deoxy-D-glucose, 2-acetamido-2-deoxy-D-galactose, D-galacturonic acid, and L-altruronic acid, the last-named sugar having not been found hitherto in O-antigens. Structure of a branched tetrasaccharide repeating unit of the polysaccharide was established by 1H and 13C NMR spectroscopy, including two-dimensional COSY and rotating-frame NOE spectroscopy. The lateral L-altruronic acid residue plays the immunodominant role in manifestation of the O10 specificity of Proteus, whereas a disaccharide fragment of the main chain in common with the O-specific polysaccharide of P. mirabilis O43 provides the one-way serological cross-reactivity between anti-O10 serum and O43-antigen.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteus mirabilis
/
Uronic Acids
/
O Antigens
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
1996
Document type:
Article
Affiliation country: