Trace analysis of albendazole and its sulphoxide and sulphone metabolites in milk by liquid chromatography.
J Chromatogr B Biomed Appl
; 687(2): 427-35, 1996 Dec 13.
Article
in En
| MEDLINE
| ID: mdl-9017467
ABSTRACT
Analytical methodology for determination of albendazole and its sulphoxide and sulphone metabolites in milk at levels down to 2-5 ng/ml has been developed. Extraction was carried out with ethyl acetate under alkaline conditions, and extracts were analyzed on a silica-based C18 column in the presence of positively-charged pairing ions. Accuracy data showed overall recoveries ranged from 78.4% to 100%, whereas precision data, based on within and between-day variation, suggested overall precision values better than 4.9%. The method was successfully applied to determine residues in milk of a dairy cow orally given albendazole.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Albendazole
/
Chromatography, Liquid
/
Milk
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
J Chromatogr B Biomed Appl
Year:
1996
Document type:
Article
Affiliation country: