Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

Phillips, G B; Buckman, B O; Davey, D D; Eagen, K A; Guilford, W J; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, D R; Mohan, R; Ng, H P; Post, J M; Shaw, K J; Smith, D; Subramanyam, B; Sullivan, M E; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, M M

Phillips, G B; Buckman, B O; Davey, D D; Eagen, K A; Guilford, W J; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, D R; Mohan, R; Ng, H P; Post, J M; Shaw, K J; Smith, D; Subramanyam, B; Sullivan, M E; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, M M.

Affiliation

Phillips GB; Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.

J Med Chem ; 41(19): 3557-62, 1998 Sep 10.

Article in En | MEDLINE | ID: mdl-9733480

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Serine Proteinase Inhibitors / Factor Xa Inhibitors / Amidines / Anticoagulants Type of study: Prognostic_studies Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1998 Document type: Article Affiliation country:

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