Effects of sodium pentobarbital on electric and mechanical activities of guinea pig papillary muscle.
Zhongguo Yao Li Xue Bao
; 17(5): 439-41, 1996 Sep.
Article
in En
| MEDLINE
| ID: mdl-9863169
AIM: To study the effects of sodium pentobarbital (SP) on the action potential (AP) and contraction of guinea pig papillary muscle. METHODS: Using conventional glass microelectrode and mechanical recording of myocardium contraction. RESULTS: SP (> or = 10 mumol.L-1) prolonged the AP duration (APD) and effective refractory period (ERP), while amplitude (APA) and Vmax of phase 0 showed no changes. The effects of SP were abolished by pretreatment with cromakalim, an agonist of ATP-sensitive K+ channel. The maximal isometric tension (Pmax) and velocity of tension development (dT/dt) were decreased to 51% and 48% of control, respectively. The first postrest beat (B1) and second postrest beat (B2) were also depressed. CONCLUSION: SP affected the action potential by reducing activities of the K+ channels and reduced the contraction of guinea pig myocardium.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pentobarbital
/
Adjuvants, Anesthesia
/
Myocardial Contraction
Limits:
Animals
Language:
En
Journal:
Zhongguo Yao Li Xue Bao
Year:
1996
Document type:
Article
Affiliation country:
Country of publication: