Iodinated Contrast Media Can Induce Long-Lasting Oxidative Stress in Hemodialysis Patients
Yonsei Medical Journal
; : 1438-1446, 2013.
Article
in En
| WPRIM
| ID: wpr-100955
Responsible library:
WPRO
ABSTRACT
PURPOSE: Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population. MATERIALS AND METHODS: We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days. RESULTS: In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure. CONCLUSION: Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Renal Dialysis
/
Oxidative Stress
/
Contrast Media
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
2013
Document type:
Article