Expressions of differential proteins in the expressed prostatic secretion of patients with III A chronic prostatitis / 中华男科学杂志
National Journal of Andrology
; (12): 780-784, 2013.
Article
in Zh
| WPRIM
| ID: wpr-268003
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expressions of differential proteins in the expressed prostatic secretion (EPS) of patients with III A chronic prostatitis and healthy men.</p><p><b>METHODS</b>We collected EPS samples from 35 patients with III A chronic prostatitis and 18 age-matched healthy men, and detected the differentially expressed proteins in EPS by MALDI-TOF/MS. Based on the data obtained, we conducted a statistical analysis on the mass-to-charge (m/z) ratios of different proteins and a retrieval analysis on the relevant proteins using the protein database.</p><p><b>RESULTS</b>In the comparative studies of the III A chronic prostatitis patients and healthy men, 5 proteins were detected as at least 2-fold differentially expressed, which were probably brevinin-2Eg, big endothelin-1, alpha-defensin 15, beta-defensin 134 and prostatic steroid-binding protein C2. The m/z ratios were significantly up-regulated in 3 372, 3 487, 425 and 5 325 Da proteins (P < 0.01) and down-regulated in 10631Da (P < 0.01).</p><p><b>CONCLUSION</b>Proteins are differentially expressed in the EPS of III A chronic prostatitis patients and healthy men, and these proteins may be significantly correlated with the development and progression of III A chronic prostatitis.</p>
Full text:
1
Database:
WPRIM
Main subject:
Prostate
/
Prostatitis
/
Body Fluids
/
Case-Control Studies
/
Chronic Disease
/
Classification
/
Endothelin-1
/
Bodily Secretions
/
Defensins
/
Metabolism
Type of study:
Observational_studies
Limits:
Adult
/
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2013
Document type:
Article