Imaging of Estrogen Receptors with Iodine-123- Iabeled Estradiol in Primary Breast Cancer Patients / 한국유방암학회지
Journal of Korean Breast Cancer Society
; : 108-112, 2002.
Article
in Ko
| WPRIM
| ID: wpr-28242
Responsible library:
WPRO
ABSTRACT
PURPOSE: We evaluated the feasibility of non-invasive imaging of estrogen receptors (ER) in primary breast cancer with iodine-123-labeled ER specific ligand (17alpha,20E)-21-[123I] iodo-19-nonpregna-1,3,5-(10), 20-tetraene-3, 17-diol using conventional nuclear medicine technique. METHODS: Before they underwent surgical management, planar scintigraphy and single-photon emission computed tomography (SPECT) were performed in 18 patients with proven primary breast cancer, after single IV injection of 5~10 mCi I-123-estradiol. The results were compared with those of immunohistochemical staining against ER of the surgical specimens. RESULTS: Planar and SPECT imaging showed hot uptake in nine of eighteen (50%) breast cancer patients. The results of ER immunohistochemistry were all positive in these patients. In the 9 cases of negative scintigraphy, 8 showed negative staining results but one showed positive staining results. Therefore, the overall concordance rate of ER scintigraphy and ER immunohistochemistry was 94.4% (17/18). CONCLUSION: ER scintigraphy using I-123-estradiol is a highly predictable in vivo technique to detect ER-positive breast cancer preoperatively. It has potential application as a re-liable diagnostic modality and indicator of hormone therapy for breast cancer patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Breast
/
Breast Neoplasms
/
Immunohistochemistry
/
Radionuclide Imaging
/
Tomography, Emission-Computed
/
Receptors, Estrogen
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Tomography, Emission-Computed, Single-Photon
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Negative Staining
/
Estradiol
/
Estrogens
Limits:
Humans
Language:
Ko
Journal:
Journal of Korean Breast Cancer Society
Year:
2002
Document type:
Article