Effect of gufuhuo decoction on local apoptosis of steroid-induced necrosis of femoral head / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1848-1851, 2005.
Article
in Zh
| WPRIM
| ID: wpr-287272
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the bone specimen of SANFH (steroid-induced avascular necrosis of femoral head) and the effect of Gufuhuo decoction on local apoptosis of SANFH.</p><p><b>METHOD</b>Model rabbits of necrosis of femoral head, made by intragluteal injection with prednisone acetate, were killed after 6 weeks to study the apoptosis by means of TUNEL.</p><p><b>RESULT</b>A great number of faded osteocytes and osteoblasts existed in specimen of SANFH. There was significant difference in apoptosis indexes between model and control group, Gufuhuo decoction and Xianlinggubao group (P < 0.05).</p><p><b>CONCLUSION</b>In the course of SANFH, the necrosis results from the interaction of apoptosis and necrosis of steroid-induced osteocytes and osteoblasts. Gufuhuo decoction has some effects on improving apoptosis and necrosis of SANFH.</p>
Full text:
1
Database:
WPRIM
Main subject:
Osteoblasts
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Osteocytes
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Pathology
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Pharmacology
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Plants, Medicinal
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Prednisone
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Drugs, Chinese Herbal
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Materia Medica
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Random Allocation
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Chemistry
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Document type:
Article