Clinical analysis of intracytoplasmic sperm injection in patients with previous fertilization failure after conventional IVF / 中华男科学杂志
National Journal of Andrology
; (12): 531-533, 2006.
Article
in Zh
| WPRIM
| ID: wpr-343580
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical outcome of intracytoplasmic sperm injection (ICSI) in patients with previous fertilization failure after conventional IVF.</p><p><b>METHODS</b>Data from 20 ICSI cases (22 ICSI cycles) with previous complete failure of fertilization or with fertilization rate < or = 20% between January 2002 and December 2004 were retrospectively analyzed. The control group consisted of 100 consecutive ICSI cycles for male factor infertility in the same period.</p><p><b>RESULTS</b>The fertilization rate dramatically increased from 5.4% after conventional IVF to 76.9% after ICSI treatment (chi-squared = 264.66, P < 0.001). However, the fertilization rate in the subgroup with previous low fertilization was significantly lower than those in the control and in the subgroup without previous fertilization (67.9% vs 77.5%, 67.9% vs 84.2%). Compared with the control group, the subgroup without previous fertilization had a higher pregnancy rate and implantation rate, but only the difference in the implantation rate was statistically significant (40.5% vs 18.9%).</p><p><b>CONCLUSION</b>ICSI can overcome previous fertilization failure with conventional in vitro fertilization and thus improve the clinical outcome.</p>
Full text:
1
Database:
WPRIM
Main subject:
Therapeutics
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Pregnancy Outcome
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Fertilization in Vitro
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Case-Control Studies
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Retrospective Studies
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Treatment Failure
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Sperm Injections, Intracytoplasmic
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Infertility
Type of study:
Observational_studies
Limits:
Adult
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Female
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Humans
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Male
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Pregnancy
Language:
Zh
Journal:
National Journal of Andrology
Year:
2006
Document type:
Article