Myostatin mRNA expression in patients of Duchenne muscular dystrophy / 中华神经科杂志
Chinese Journal of Neurology
; (12): 750-753, 2011.
Article
in Zh
| WPRIM
| ID: wpr-420059
Responsible library:
WPRO
ABSTRACT
Objective To explore the expression of myostatin mRNA,a negative regulator of muscle growth,in the skeletal muscle of Duchenne muscular dystrophy(DMD)patients.Methods A semi-quantitative reverse transcription polymerase chain reaction was performed to evaluate the expression of myostatin in the skeletal muscle of 7 DMD patients and 4 healthy controls.Results The level of myostatin gene expression in the skeletal muscle of DMD patients was higher than that of healthy controls(0.56 ± 0.16 vs 0.34 ± 0.15,Z =-2.268,P =0.023).Conclusions The myostatin gene expression was increased in the DMD patients compared to the healthy controls.Enhanced expression of myostatin in the skeletal muscle might be involved in the pathogenesis of DMD.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Neurology
Year:
2011
Document type:
Article