The incidence of heparin-induced thrombocytopenia and positivity of antibody in patients treated with heparin preparations / 中华内科杂志
Chinese Journal of Internal Medicine
; (12): 734-736, 2013.
Article
in Zh
| WPRIM
| ID: wpr-442124
Responsible library:
WPRO
ABSTRACT
Objectives To investigate the incidence of the heparin-induced thrombocytopenia (HIT) and positivity of anti-heparin/platelet factor 4 complex antibody (HIT-antibody) in inpatients treated with heparin preparations.Methods A total of 197 consecutive patients,including 120 men and 77 women,who were treated with unfractioned heparin (UFH) or low molecular weight heparin (LMWH),were enrolled in this study.HIT-antibody was detected by enzyme-linked immunosorbent assay (ELISA).All patients were classified into subgroups based on 4Ts (Pretest Clinical Scoring System) and types of underlying disorders.The incidence of HIT and positivity of HIT-antibody among different groups were analyzed.Results The overall incidence of HIT was 3.0% (6/197),and the positivity of HIT antibody was 12.2% (24/197).The positivity of HIT-antibody was 10.1% (18/178),7.7% (1/13) and 83.3%(5/6) in low,moderate and high HIT probability group respectively.There were significant differences of HIT positivity and mean level of HIT-antibody between the high HIT probability group and the low or moderate HIT probability group (P =0.000).Both the incidence of HIT and positivity of HIT-antibody were higher in surgical patients than in medical patients (5.8% vs 0.9%,P =0.047 and 19.8% vs 6.3%,P =0.004).Conclusions The incidence of HIT and positivity of HIT-antibody were 3.0% and 12.2% respectively,both of which were related with the types of disorders.Detection of HIT-antibody has a better applicable value in patients with high HIT probability.
Full text:
1
Database:
WPRIM
Type of study:
Incidence_studies
Language:
Zh
Journal:
Chinese Journal of Internal Medicine
Year:
2013
Document type:
Article