Experimental characteristics of creating animal models of osteosarcoma / 中国组织工程研究

ABSTRACT

Presently,studies of onset,development and tumor drug resistance of osteosarcoma were few.Further studies on tumor animal models can provide a promising basis for treating osteosarcoma.Commonly used animal models of osteosarcoma include mouse,rat,rabbit and dog.Organs of rats are similar to human,so does genotype.Dogs can spontaneously develop osteosarcoma,which is similar to human,and are frequently used as spontaneous tumor models.However,there are some differences in biological features,pathogenic mechanism and histology.With the development of studying,there will be more and more new animal models in accordance with human osteosarcoma characteristics.The present study served to review methods of establishing models,characteristics and detailed application of animal models of osteosarcoma.