Risk Factors for Late-onset Hyponatremia and Its Influence on Neonatal Outcomes in Preterm Infants
Journal of Korean Medical Science
; : 456-462, 2015.
Article
in En
| WPRIM
| ID: wpr-61307
Responsible library:
WPRO
ABSTRACT
Late-onset hyponatremia (LOH), hyponatremia occurring after two weeks of age with the achievement of full feeding, is the result of a negative sodium balance caused by inadequate salt intake or excessive salt loss due to immature renal or intestinal function in preterm infants. The aims of our study were to identify the risk factors for LOH and its influence on neonatal outcomes. This was a retrospective cohort analysis of 161 preterm infants born before 34 weeks of gestation between June 2009 and December 2010 at Seoul National University Hospital. LOH was defined as a sodium level < or = 132 mEq/L or 133-135 mEq/L with oral sodium supplementation. LOH occurred in 49 (30.4%) of the studied infants. A lower gestational age, a shorter duration of parenteral nutrition, the presence of respiratory distress syndrome, the use of furosemide, and feeding with breast milk were significant risk factors for LOH. In terms of neonatal outcomes, the infants with LOH had longer hospital stays and higher risks of bronchopulmonary dysplasia and retinopathy of prematurity requiring surgery. LOH lasting at least 7 days significantly increased moderate to severe bronchopulmonary dysplasia, periventricular leukomalacia, and extra-uterine growth retardation. LOH is commonly observed in preterm infants; it may be a risk factor for bronchopulmonary dysplasia and retinopathy of prematurity or a marker of illness severity.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Bronchopulmonary Dysplasia
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Infant, Premature
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Logistic Models
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Retrospective Studies
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Risk Factors
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Cohort Studies
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Hyponatremia
Type of study:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Female
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Humans
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Male
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Newborn
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2015
Document type:
Article