Squamous Metaplasia and BCL-6 in Pediatric Adenoid Accompanied by Otitis Media with Effusion
Yonsei Medical Journal
; : 449-456, 2007.
Article
in En
| WPRIM
| ID: wpr-71495
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Deterioration of local immunity in the adenoids may make them vulnerable to infection by microorganisms, resulting in otitis media with effusion. To determine the factors associated with this condition, we evaluated adenoid size, mucosal barrier, squamous changes of ciliated epithelium, IgA secretion, and BCL-6 expression in adenoids. MATERIALS ANDMETHODS:
Seventeen children diagnosed with otitis media with effusion (OME group) and 20 children without any history of OME (control group) were enrolled. Their adenoids were sized by lateral view X-ray and stained with hematoxylin and eosin to detect squamous metaplasia. The adenoids were also stained with cytokeratin to evaluate mucosal barriers, and with anti- IgA antibody and anti- BCL-6 antibody to determine expression of IgA and BCL-6.RESULTS:
The OME group showed greater incidence of squamous metaplasia, fewer ciliated cells, and lower expression of BCL-6 (p 0.05). IgA secretion and adenoid size were the same for the OME and the control groups.CONCLUSION:
These results suggest that increased squamous metaplasia and lower BCL-6 expression in adenoids may be associated with increased susceptibility to OME.Key words
Full text:
1
Database:
WPRIM
Main subject:
Otitis Media with Effusion
/
Immunoglobulin A
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Immunohistochemistry
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Adenoids
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Proto-Oncogene Proteins c-bcl-6
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Keratins
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Metaplasia
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Mucous Membrane
Limits:
Child
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Child, preschool
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Female
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Humans
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Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
2007
Document type:
Article