Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis
Kidney Research and Clinical Practice
; : 205-211, 2019.
Article
in En
| WPRIM
| ID: wpr-758989
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Elevated serum alkaline phosphatase (AP) and γ-glutamyl transferase (γ-GT) are commonly observed in patients with acute pyelonephritis. The goal of this study was to examine the clinical significance of elevated serum AP and γ-GT levels and to explore the mechanisms underlying these changes.METHODS:
We examined serum AP and γ-GT levels in 438 patients with acute pyelonephritis. Urine AP/creatinine (Cr), urine γ-GT/Cr, fractional excretion of AP, and fractional excretion of γ-GT (FE(γ-GT)) were evaluated in patients with elevated and normal serum levels. AP isoenzymes were also examined.RESULTS:
We identified 77 patients (17.6%) with elevated serum AP and 134 patients (30.6%) with elevated serum γ-GT. Among them, both enzymes were elevated in 64 patients (14.6%). Older age, longer hospital stay, elevated baseline serum Cr, and complicated pyelonephritis were associated with increases in serum AP and γ-GT. Multivariate analysis showed that high serum AP levels were significantly correlated with renal impairment (odds ratio, 2.13; 95% confidence interval, 1.08–4.19; P = 0.029). FE(γ-GT) was significantly lower in patients with elevated serum enzyme levels. The liver fraction for AP isoenzyme profile did not increase in patients with elevated serum AP.CONCLUSION:
Our results demonstrated that elevated serum AP and γ-GT levels are associated with complicated pyelonephritis and renal impairment. Lower FE(γ-GT) levels in patients with elevated serum enzymes may be the result of decreased urinary excretion of these enzymes.Key words
Full text:
1
Database:
WPRIM
Main subject:
Pyelonephritis
/
Transferases
/
Multivariate Analysis
/
Alkaline Phosphatase
/
Gamma-Glutamyltransferase
/
Isoenzymes
/
Length of Stay
/
Liver
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Kidney Research and Clinical Practice
Year:
2019
Document type:
Article