Clinical Research on Alzheimer's Disease: Progress and Perspectives / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1111-1118, 2018.
Article
in En
| WPRIM
| ID: wpr-775511
Responsible library:
WPRO
ABSTRACT
Alzheimer's disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Therapeutics
/
Blood
/
Magnetic Resonance Imaging
/
Biomarkers
/
Disease Progression
/
Biomedical Research
/
Diagnosis
/
Alzheimer Disease
/
Methods
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Neuroscience Bulletin
Year:
2018
Document type:
Article