Two new C steroidal glycosides isolated from Cynanchum komarovii / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 610-614, 2018.
Article
in En
| WPRIM
| ID: wpr-812369
Responsible library:
WPRO
ABSTRACT
The present study was designed to further investigate the C steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 1414, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC values ranging from 16.6 to 26.3 μmol·L, compared to the positive control 5-fluorouracil (6.4 μmol·L).
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Steroids
/
Drugs, Chinese Herbal
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
HL-60 Cells
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Cynanchum
/
Glycosides
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article