Expression and clinical significance of B3GNT3 in pancreatic cancer / 国际生物医学工程杂志

ABSTRACT

Objective:To detect the expression of β-1, 3-N-acetylglucosamine aminotransferase 3 (B3GNT3) in pancreatic cancer tissues and analyze its clinical significance.Methods:Bioinformatics methods were used to analyze the mRNA levels of B3GNT3 in pancreatic cancer tissues and normal tissues, and to analyze the relationship between its expression and the survival rate of pancreatic cancer patients. The clinicopathological data of 78 patients with pancreatic cancer undergoing surgical treatment were retrospectively analyzed. Immunohistochemical method was used to detect the expression level of B3GNT3 protein in pancreatic cancer tissue and normal tissues, and to analyze its relationship with clinicopathological characteristics of patients with renal clear cell carcinoma.Results:The results of bioinformatics analysis showed that B3GNT3 mRNA was significantly highly expressed in pancreatic cancer tissues, and was significantly related to the overall survival rate and disease-free survival rate of the patients. The results of immunohistochemistry showed that the expression of B3GNT3 in pancreatic cancer tissues was significantly higher than that in normal tissues. The high expression of B3GNT3 in pancreatic cancer tissue was related to tumor stage, tumor size and lymph node metastasis (all P<0.05), but not related to age, gender, and tumor grade (all P>0.05). Conclusions:B3GNT3 plays an important role in the progression and evolution of pancreatic cancer, and is expected to become an important therapeutic target and a potential biomarker for pancreatic cancer.