Thromboxane in Pregnancy-Induced Hypertension / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1680-1683, 2004.
Article
in En
| WPRIM
| ID: wpr-86330
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: High thromboxane level evidence supports pivotal involvement of TxA2 in pathophysiology of pregnancy induced hypertension and provides a strong rationale for pursuing TxA2-blocking strategies in drug development. METHODS: The stable metabolites of TXA2 (Thromboxane B2) in maternal blood of 12 patients with mild preeclampsia, 4 patients with severe preeclampsia and 14 normal parturients were measured by competitive enzyme immunoassay. RESULTS: TxB2 concentrations were not increased in mild preeclampsia (101 +/- 12 pg/mL, n=12) as compared with normal pregnancy (150 +/- 15 pg/mL, n=14), but they were significantly increased in severe preeclampsia (454 +/- 102 pg/mL, p<0.0001, n=4). CONCLUSION: Maternal plasma thromboxane is increased only in severe preeclampsia. Thus, increased thromboxane A2 biosynthesis correlates with disease severity and may have a pathogenetic role in pregnancy-induced hypertension. These findings provide a rationale for the use of aspirin in the treatment as well as in the prevention of this disorder.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Plasma
/
Pre-Eclampsia
/
Thromboxane A2
/
Aspirin
/
Immunoenzyme Techniques
/
Hypertension, Pregnancy-Induced
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2004
Document type:
Article