The assessment of B-type natriuretic peptide be used as a prognositic factor for community-acquired pneumonia / 中国医师杂志

ABSTRACT

Objective To explore the value of B-type natriuretic peptide (BNP) be used as a prognostic factor for community-acquired pneumonia.Methods This was a multicenter,retrospective study.Data of patients hospitalized with community-acquired pneumonia during 2014/1/1 to 2015/12/31 from four tertiary hospitals were reviewed,including demographic and clinical features,and outcomes.Univariate analysis and logistic regression analysis were performed to determine risk factors for 30-day mortality.Receiver operating characteristic curves (ROCs) was performed to verify the accuracy of BNP ＞ 1 000 pg/ml,CURB-65 score and BNP ＞ 1 000 pg/ml + CURB-65 score (B-CURB65) as 30-day mortality predictors in the study patients.Results 1 786 patients hospitalized with community-acquired pneumonia (CAP) were entered into the final analysis.The 30-day mortality was 4.7％.Logistic regression analysis confirmed blood BNP ＞ 1 000 pg/ml was an independent risk factor associated with 30-day mortality of CAP patients.The area under the curve (AUC) of B-CURB65 was 0.774,which was higher than CURB-65 score (AUC =0.625,P =0.002).Conclusions Blood BNP is a valuable biomarker related to the 30-day mortality of CAP patients,which can increase the predicting accuracy of CURB-65 score.