Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
Braz. J. Pharm. Sci. (Online)
; 54(4): e17242, 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1001571
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (6238, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Farmacocinética
/
Cromatografia Líquida
/
Portulaca
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Liaoning University of Traditional Chinese Medicine/CN
/
National Institute for Radiological Protection/CN