Association between hematological parameters and iron metabolism response after marathon race and ACTN3 genotype
Front Physiol
; 10(697)Jun. 2019. tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1009235
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
αlpha-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, hematological parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, na elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight protective role of the XX genotype on hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
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SESSP-IDPCPROD
Assunto principal:
Treinamento Intervalado de Alta Intensidade
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Genótipo
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Hematologia
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Metabolismo
Tipo de estudo:
Fatores de risco
Aspecto:
Determinantes sociais da saúde
Limite:
Humanos
Idioma:
Inglês
Revista:
Front Physiol
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Biodynamics of Human Movements, School of Physical Education and Sports, University of Sao Paulo/BR
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Department of Biodynamics of Human Movements, School of Physical Education and Sports, University of Sao Paulo/BR
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Department of Biophysics, Federal University of Sao Paulo/BR
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Department of Interdisciplinary in Health Sciences, Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University/BR
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Neuromuscular Research, Murdoch Children's Research Institute/AU
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Sports Cardiology Department, Dante Pazzanese Institute of Cardiology/BR